The Parkinson’s Protocol™ By Jodi Knapp Parkinson’s disease cannot be eliminated completely but its symptoms can be reduced, damages can be repaired and its progression can be delayed considerably by using various simple and natural things. In this eBook, a natural program to treat Parkinson’s disease is provided online. it includes 12 easy steps to repair your body and reduce the symptoms of this disease. The creator of this program has divided into four segments to cover a complete plan to treat this disease along with improving your health and life by knowing everything about this health problem. The main focus of this program is on boosting the levels of hormone in your brain by making e a few easy changes in your lifestyle, diet, and thoughts
What new medications are being developed for Parkinson’s disease?
Several new medications and treatments for Parkinson’s disease are currently being developed, aiming to improve motor and non-motor symptoms, slow disease progression, or modify the disease altogether. Here are some promising approaches:
1. Gene Therapy
- Voyager Therapeutics’ VY-AADC: This therapy focuses on enhancing the brain’s ability to convert levodopa into dopamine. It targets the AADC enzyme, which is crucial for dopamine production, and helps reduce fluctuations in motor symptoms.
- Axovant’s AXO-Lenti-PD: This therapy delivers a lentiviral vector to the brain to restore dopamine levels. Early trials have shown promise in improving motor function.
2. Alpha-Synuclein Targeted Therapies
Alpha-synuclein is a protein that accumulates abnormally in the brains of people with Parkinson’s.
- Prasinezumab (Roche/Prothena): A monoclonal antibody that aims to slow down the accumulation of alpha-synuclein, potentially slowing disease progression.
- BIIB122 (Biogen): Another anti-alpha-synuclein therapy that targets early-stage Parkinson’s and aims to reduce the spread of misfolded proteins.
3. Levodopa Formulations
Levodopa remains the gold standard treatment for Parkinson’s motor symptoms, but several new formulations aim to improve its efficacy and reduce side effects.
- IPX203 (Amneal Pharmaceuticals): An extended-release formulation of levodopa that helps smooth out motor fluctuations by providing more consistent delivery of the drug.
- Accordion Pill: This is an innovative oral formulation that releases levodopa in a more controlled manner, improving “off” periods when medication wears off.
4. Dopamine Agonists
New dopamine agonists are being developed to better mimic dopamine’s action in the brain.
- D-512: A new dopamine receptor modulator with both dopamine-enhancing and neuroprotective properties, targeting motor and non-motor symptoms with fewer side effects.
5. Glial Cell Line-Derived Neurotrophic Factor (GDNF)
GDNF is a protein that may protect and regenerate dopamine neurons. Clinical trials are exploring the direct infusion of GDNF into the brain, potentially reversing disease progression. A recent trial showed some promise, though more research is needed.
6. Inflammation Modulators
Inflammation is increasingly recognized as a key contributor to Parkinson’s.
- NLY01 (Neuraly): A drug that targets glial cells (the brain’s immune cells) to reduce inflammation and protect neurons, possibly slowing disease progression.
- Ambroxol: This medication, originally used for respiratory conditions, is being explored for its ability to clear out abnormal proteins and reduce neuroinflammation.
7. Repurposing Drugs
- Exenatide (GLP-1 receptor agonist): Originally a diabetes drug, exenatide has shown neuroprotective effects and is being tested for its ability to slow Parkinson’s progression.
- Istradefylline: Recently approved by the FDA, this drug targets adenosine A2A receptors and can be added to existing therapies to help reduce “off” periods.
These developments are promising, but many of them are still in clinical trial stages, with full approval likely some years away. However, they represent exciting advancements in the search for better treatment options for Parkinson’s disease.
The Parkinson’s Protocol™ By Jodi Knapp Parkinson’s disease cannot be eliminated completely but its symptoms can be reduced, damages can be repaired and its progression can be delayed considerably by using various simple and natural things. In this eBook, a natural program to treat Parkinson’s disease is provided online. it includes 12 easy steps to repair your body and reduce the symptoms of this disease. The creator of this program has divided into four segments to cover a complete plan to treat this disease along with improving your health and life by knowing everything about this health problem. The main focus of this program is on boosting the levels of hormone in your brain by making e a few easy changes in your lifestyle, diet, and thoughts