How does neuropathy affect the gastrointestinal system?

December 3, 2024


Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.


How does neuropathy affect the gastrointestinal system?

Neuropathy can significantly affect the gastrointestinal (GI) system, particularly when it involves the autonomic nervous system, which controls involuntary functions, including digestion. Gastrointestinal neuropathy is a condition in which the nerves that regulate the GI tract become damaged, leading to various digestive issues. Here’s how neuropathy can impact the gastrointestinal system:

1. Autonomic Neuropathy and Its Impact on Digestion

The autonomic nervous system (ANS) controls several processes related to digestion, including motility (the movement of food through the digestive tract), enzyme secretion, and blood flow to the gut. When neuropathy affects the ANS, these processes can become impaired, leading to a variety of gastrointestinal symptoms:

  • Gastroparesis: One of the most common gastrointestinal problems caused by autonomic neuropathy is gastroparesis, a condition in which the stomach empties too slowly. This can lead to nausea, vomiting, bloating, early satiety (feeling full quickly after eating), and abdominal discomfort. Gastroparesis is often seen in people with diabetes and can be a result of diabetic neuropathy affecting the nerves that control the stomach muscles.
  • Constipation: Neuropathy can cause dysfunction in the nerves that control the bowel muscles, leading to chronic constipation. The normal coordinated contractions of the colon may be impaired, making it difficult for food to move through the intestines properly. This can result in abdominal pain, bloating, and discomfort.
  • Diarrhea: On the other hand, some individuals with neuropathy, particularly those with diabetic autonomic neuropathy, may experience diarrhea due to impaired regulation of the bowel muscles, leading to increased frequency of bowel movements and urgency.
  • Fecal Incontinence: Damage to the nerves controlling the anal sphincter can lead to fecal incontinence, or the inability to control bowel movements. This is often due to damage to the sensory or motor nerves that regulate bowel movements.
  • Dysphagia: Neuropathy can also affect the nerves responsible for swallowing, leading to difficulty swallowing, a condition called dysphagia. This can make it hard to swallow food or liquids and may cause choking or aspiration (food entering the windpipe instead of the esophagus).

2. Altered Gastrointestinal Motility

Nerves in the gastrointestinal tract help coordinate the smooth muscle contractions that move food through the system. Neuropathy can disrupt this motility, causing:

  • Delayed or irregular gastric emptying: This can result in bloating, nausea, and a sensation of fullness after eating only a small amount of food.
  • Reduced peristalsis: Peristalsis refers to the wave-like muscle contractions that push food through the digestive system. Neuropathy can impair peristalsis, leading to difficulty with food processing and absorption.
  • Gastroesophageal reflux disease (GERD): Neuropathy can interfere with the functioning of the lower esophageal sphincter (LES), a muscle that prevents stomach acid from flowing back into the esophagus. This can lead to acid reflux and heartburn.

3. Blood Flow and Absorption Issues

The autonomic nervous system also regulates blood flow to the digestive organs, which is necessary for proper digestion and nutrient absorption. Neuropathy can affect this regulation, leading to:

  • Impaired nutrient absorption: Damage to the autonomic nerves can affect the efficiency of nutrient absorption in the intestines. This may result in malabsorption, where essential nutrients (such as vitamins and minerals) are not adequately absorbed, leading to deficiencies.
  • Altered gut microbiota: Neuropathy may influence the balance of gut bacteria, which can affect digestion and contribute to symptoms like bloating, gas, and discomfort.

4. Pain and Sensory Issues

Neuropathy can cause abnormal sensory perceptions in the gastrointestinal system, leading to sensations like:

  • Abdominal pain: Damaged nerves can cause chronic or intermittent pain in the abdomen, often accompanied by bloating or discomfort.
  • Altered taste and appetite: Neuropathy can affect the taste buds and appetite-regulating mechanisms in the brain, leading to changes in food preferences, reduced appetite, or an abnormal sense of taste.

5. Impact of Diabetes on GI Neuropathy

One of the most common causes of gastrointestinal neuropathy is diabetic neuropathy. High blood sugar levels over time can damage the nerves that control the gastrointestinal system, leading to a variety of digestive issues, such as gastroparesis, constipation, diarrhea, and bloating. Managing blood glucose levels is essential to prevent or manage gastrointestinal neuropathy in diabetic patients.

6. Treatment and Management

Management of gastrointestinal neuropathy depends on the underlying cause and the specific symptoms. Common approaches include:

  • Medications: For gastroparesis, medications like prokinetics (e.g., metoclopramide) can help promote stomach emptying. In some cases, medications like anticholinergics or antidiarrheals may be used to address other GI symptoms.
  • Dietary changes: A diet tailored to the individual’s symptoms can help manage gastrointestinal issues. For example, small, frequent meals and low-fat, low-fiber foods may be recommended for people with gastroparesis, while high-fiber diets can be beneficial for those with constipation.
  • Blood sugar control: For individuals with diabetes, tight control of blood glucose levels is crucial in preventing or slowing the progression of diabetic neuropathy and its gastrointestinal effects.
  • Physical therapy and lifestyle modifications: Exercise, hydration, and stress management may also play a role in improving gastrointestinal motility and overall digestive health.

In conclusion, neuropathy can have a significant impact on the gastrointestinal system by disrupting motility, causing malabsorption, and leading to symptoms such as constipation, diarrhea, bloating, and pain. Proper management of the underlying causes and symptoms can help alleviate these issues and improve quality of life. If you suspect neuropathy is affecting your gastrointestinal system, it’s important to consult with a healthcare provider for an accurate diagnosis and treatment plan.


Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.