Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.
How does chronic alcohol use lead to neuropathy?
Long-term alcohol use can lead to neuropathy—alcoholic neuropathy—through several interrelated mechanisms:
1. Direct Nerve Toxicity
Alcohol and its metabolite, acetaldehyde, are neurotoxins. They damage the axon (the long part of the nerve fiber) and the myelin sheath (the insulating layer), disrupting signal conduction. This leads to degeneration of peripheral nerves in the long term.
2. Nutritional Deficiencies
Alcohol interferes with the absorption and utilization of necessary nutrients essential for nerve function:
Thiamine (Vitamin B1): Required for nerve function; deficiency leads to axonal degeneration.
Vitamin B6, B12, niacin, and folate: Required for repair of myelin and synthesis; deficiency can lead to demyelination and damage to nerves.
Poor nutrition among chronic alcoholics worsens these deficiencies.
3. Oxidative Stress and Inflammation
Alcohol increases oxidative stress in nerve cells and causes chronic inflammation, both of which damage and kill nerve cells.
4. Liver Damage (Indirect Effect)
Liver damage from chronic alcohol intake (e.g., cirrhosis) can lead to metabolic disturbances, including elevated ammonia and impaired detoxification. Systemic changes can further harm nerve tissue.
5. Mitochondrial Dysfunction
Mitochondrial function in neurons is repressed by alcohol, reducing energy delivery and increasing cell vulnerability to stress and injury.
Symptoms of Alcoholic Neuropathy:
Numbness or tingling (especially in hands and feet)
Burning pain
Muscle weakness
Impaired coordination
Sensitivity to touch
Digestive disturbances (in severe cases)
Do you want to know what is done to reverse or treat alcoholic neuropathy?
Genetic factors can also play a significant role in neuropathy, particularly when the neuropathy is inherited or there is a family history. This is how genetics may be involved:
1. Inherited Neuropathies
These are caused by direct gene mutations that are inherited from generation to generation. Examples include:
Charcot-Marie-Tooth disease (CMT): One of the most common inherited peripheral neuropathies. Mutations affect myelin or axonal proteins.
Hereditary sensory and autonomic neuropathies (HSAN): A group of sensory and autonomic nerve disorders.
Familial amyloid polyneuropathy (FAP): Due to TTR gene mutations, leading to amyloid deposits that degenerate nerves.
2. Genetic Predisposition
In some acquired neuropathies (e.g., diabetic or autoimmune neuropathies), genetics may not be the direct cause but may:
Influence susceptibility (for example, how an individual metabolizes glucose or responds to inflammation).
Influence the body’s capacity to heal nerve damage.
3. Mitochondrial Disorders
Mitochondrial DNA mutations, inherited from the mother, can also lead to neuropathy. These are often accompanied by other systemic symptoms like muscle weakness or hearing loss.
4. Gene-Environment Interaction
Genetic susceptibilities can predispose to neuropathy if coupled with environmental insults (for example, toxins, diet, or infection).
Do you want information about genetic testing opportunities for neuropathies?
Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.