What is neuropathy?

May 9, 2025


Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.


What is neuropathy?

Neuropathy is damage or dysfunction of the nerves in the body, which most often results in symptoms such as pain, numbness, tingling, and weakness. Neuropathy can affect any type of nerve, but most often affects the peripheral nerves, which are the nerves located outside of the spinal cord and brain. Peripheral neuropathy is most often the term used when it affects the peripheral nerves.

Types of Neuropathy
There are several various neuropathies, which occur in various nerve groups or areas of the body:

Peripheral Neuropathy:

This is the most common form and affects the nerves outside the brain and spinal cord (the peripheral nervous system).

It can cause pain, numbness, and tingling in the hands, feet, or limbs. It can also impair muscle strength and coordination.

Diabetes, alcoholism, infection, trauma, and vitamin deficiency are typical causes.

Autonomic Neuropathy:

This impinges on the autonomic nerves, which regulate involuntary body functions like blood pressure, heart rate, digestion, and breathing.

It can produce such symptoms as gastrointestinal disorders, bladder incontinence, fluctuation in blood pressure, and irregularities in the heart rate.

Diabetes mellitus is the most common cause of autonomic neuropathy.

Cranial Neuropathy:

It affects the cranial nerves, which regulate senses like vision, hearing, smell, and face sensation.

They can produce such symptoms as diplopia, or face drooping.

Focal Neuropathy:

It is a form of neuropathy that affects a specific nerve or group of nerves, leading to pain or weakness in a single area of the body.

It usually happens suddenly and can affect nerves in the face, trunk, or legs.

Causes of Neuropathy
Neuropathy can be caused by a number of factors, and the causes are usually categorized into medical illnesses, habits of lifestyle, or injury to the body:

Chronic Diseases:

Diabetes mellitus is one of the most common causes of neuropathy, leading to a resultant diabetic neuropathy.

Liver disease, chronic kidney disease, and hypothyroidism also lead to neuropathy.

Vitamin Deficiencies:

Vitamin B12 deficiency is a common peripheral neuropathy cause. Other deficiencies, including those of B1 (thiamine), B6, and E, also lead to nerve damage.

Infections:

Certain infections, including shingles (herpes zoster), HIV/AIDS, and Lyme disease, lead to neuropathy.

Alcoholism

Long-term alcohol consumption can lead to alcoholic neuropathy, which is usually caused by nutritional deficiencies, the toxic effects of alcohol, or liver disease.

Physical Trauma or Injury:

Nerve compression due to such conditions as carpal tunnel syndrome, slipped discs, or trauma (e.g., from accident trauma) can lead to neuropathy.

Medications and Toxins:

Some chemotherapy drugs, antibiotics, and infection- or disease-fighting drugs are toxic to nerves. Toxins or heavy metal exposure is yet another reason for neuropathy.

Autoimmune Disorders:

Autoimmune disorders like lupus, rheumatoid arthritis, and Guillain-Barré syndrome can cause the immune system to turn against nerves and produce neuropathy.

Hereditary Disorders:

There are genetic neuropathies, such as in Charcot-Marie-Tooth disease, which is a genetic disorder of peripheral nerves.

Symptoms of Neuropathy
The symptoms of neuropathy vary with the type of nerves involved and the etiology. Some of the frequent symptoms are:

Pain: Burning, sharp, or stabbing pain, frequently in the extremities.

Numbness: Loss of feeling, typically in the hands or feet.

Tingling or “Pins and Needles”: Typically a tingling or pricking sensation.

Weakness: Muscle weakness or loss of coordination of movements.

Sensitivity to the Touch: Light touch is sometimes painful.

Digestive Problems: Difficulty swallowing, bloating, or constipation (in autonomic neuropathy).

Balance Problems: Loss of coordination and repeated falls.

Diagnosis of Neuropathy
A doctor will typically perform a combination of the following to diagnose neuropathy:

Medical History and Physical Exam: To identify potential causes and assess the symptoms.

Blood Tests: To detect conditions like diabetes, vitamin deficiencies, or autoimmune disorders.

Nerve Conduction Studies: To measure how well nerves conduct electricity.

Electromyography (EMG): To assess the electrical activity of muscles and to detect nerve damage.

Imaging: If there has been injury or compression, imaging tests like MRI or CT scans may be used.

Treatment of Neuropathy
Treatment of neuropathy depends on the underlying cause but generally includes:

Medications

Pain management: Over-the-counter painkillers (acetaminophen, ibuprofen) or prescription medications like antidepressants or anticonvulsants (e.g., gabapentin, pregabalin) can be employed to manage pain.

Topical agents: Patches or creams, e.g., capsaicin cream, can be employed to alleviate pain in a localized area.

Physical therapy: For strengthening, balance improvement, and movement enhancement.

Lifestyle changes:

Management of underlying conditions: Managing diabetes, correcting vitamin deficiencies, and alcohol avoidance can minimize symptoms.

Dietary changes: An adequate diet rich in vitamins that are needed (e.g., B12, folic acid) may avert further nerve damage.

Surgical treatment: If neuropathy is due to compression of a nerve (e.g., carpal tunnel syndrome), operation is necessary.

Alternative treatments:
Acupuncture, biofeedback, and transcutaneous electrical nerve stimulation (TENS) can provide relief to some patients.

Prevention of Neuropathy
While prevention of all neuropathy is impossible, keeping a watch on underlying conditions and maintaining a healthy lifestyle can reduce the risk:

Control blood sugar if diabetic.

Have a balanced diet rich in necessary vitamins and nutrients.

Avoid excessive use of alcohol.

Practice good ergonomics and take a break from repetitive movements to avoid nerve compression.

Exercise regularly to maintain circulation and muscle strength.

Conclusion
Neuropathy is a condition in which the nerves are injured, leading to symptoms like pain, numbness, and weakness. Neuropathy can be caused by numerous factors, such as diabetes, infections, trauma, and vitamin deficiencies. Early treatment and diagnosis are essential to prevent further nerve injury and improve quality of life. If you suspect neuropathy, it is recommended that you consult medical advice for proper diagnosis and treatment.

If you require more information about the management of neuropathy or regarding some specific treatments, just ask!

Neuropathy is damage or dysfunction of the nerves, and it can involve any part of the nervous system and lead to symptoms like numbness, tingling, weakness, and pain. Neuropathy can come in many shapes depending on its cause, nerve affected, and pattern of symptoms. Below are the most familiar types of neuropathy:

1. Peripheral Neuropathy
Definition: The most common form of neuropathy, affecting the peripheral nervous system, which includes nerves outside the spinal cord and brain.

Causes: Often due to diabetes, alcoholism, trauma, infections, or exposure to toxins (e.g., chemotherapy).

Symptoms: Numbness, tingling, pain (especially in the feet and hands), weakness of muscles, and difficulty with coordination.

Subtypes:

Diabetic Neuropathy: A peripheral neuropathy resulting from poorly controlled diabetes.

Alcoholic Neuropathy: Due to long-term alcohol use, leading to nerve damage.

Chemotherapy-Induced Neuropathy: Due to chemotherapy drugs, leading to nerve damage, ultimately to the hands and feet.

2. Autonomic Neuropathy
Definition: Affects the autonomic nervous system, which controls involuntary body processes such as heart rate, blood pressure, digestion, and sweating.

Causes: Mostly associated with diabetes, but also because of autoimmune disease (e.g., Guillain-Barré syndrome), alcoholism, HIV, and certain medications.

Symptoms: Trouble with blood pressure control, heart rate, digestion (e.g., bloating, diarrhea, constipation), inability to sweat, and sexual dysfunction.

3. Focal Neuropathy
Definition: Affects one nerve or group of nerves in a specific area, typically resulting in sudden, severe pain.

Causes: Can be caused by diabetes, trauma, infection, or inflammation (e.g., vascular diseases).

Symptoms: Sudden weakness, pain, or loss of function in a specific area, such as in the eyes (e.g., double vision), wrists, or legs. It can also affect the cranial nerves, leading to issues such as facial paralysis (Bell’s palsy).

4. Cranial Neuropathy
Definition: Affects the brain’s nerves and can lead to vision, facial sensations, eye movements, or swallowing problems.

Causes: Typically caused by diabetes, vascular problems, tumors, or trauma.

Symptoms: Vision changes, facial weakness or paralysis, difficulty with swallowing or speech, and loss of facial sensation.

Common example: Bell’s Palsy (one-sided facial nerve paralysis).

5. Proximal Neuropathy (Diabetic Amyotrophy)
Definition: A type of neuropathy that develops in the hips, thighs, or buttocks, which is usually seen in diabetic patients.

Causes: Generally caused by diabetes, but can also be due to autoimmune conditions.

Symptoms: Sudden, severe pain or weakness in the buttock, thigh, or hip area, difficulty standing from sitting, muscle wasting.

6. Radiculopathy
Definition: A term used for nerve root irritation or compression, typically in the spine.

Causes: It could be caused by a herniated disc, spinal stenosis, or degenerative disc disease.

Symptoms: Pain, numbness, tingling, or weakness in the path of the affected nerve, typically in the neck or lower back.

7. Polyneuropathy
Definition: A type of neuropathy affecting more than one peripheral nerve, typically bilaterally, starting in the hands and feet.

Causes: Typically associated with diabetes, autoimmune disease (e.g., Guillain-Barré syndrome), toxins, infection, and genetic disorders.

Symptoms: Numbness, tingling, pain, or weakness in the hands and feet, which can extend up the limbs. It can also lead to muscle weakness and impaired coordination.

8. Hereditary Neuropathy
Definition: Conditions inherited that lead to neuropathy, often affecting multiple nerves.

Causes: Due to inherited mutations in genes that affect nerve function, e.g., in Charcot-Marie-Tooth disease.

Symptoms: Gradual weakness and atrophy (muscle wasting), sensory loss, and deformities in the hands, feet, or legs.

9. Entrapment Neuropathy
Definition: Occurs when a nerve is compressed or entrapped in a single location, most often due to repetitive pressure or motion.

Causes: Can be caused by repetitive motion, overuse, compression, or trauma.

Examples:

Carpal Tunnel Syndrome (median nerve compression at the wrist).

Cubital Tunnel Syndrome (ulnar nerve compression at the elbow).

Tarsal Tunnel Syndrome (tibial nerve compression at the ankle).

10. Small Fiber Neuropathy
Definition: Affects the small sensory nerve fibers that are responsible for pain conduction and sensation.

Causes: Often associated with diabetes, autoimmune diseases, infection, or idiopathic (no known cause) etiologies.

Symptoms: Pain, burning, or numbness in the hands and feet, or temperature or sensation changes (such as loss of ability to detect light touch).

11. Hereditary Neuropathies
Definition: Genetic conditions leading to neuropathy, typically progressive.

Causes: Genetic mutation that leads to irregular development or nourishment of nerve fibers.

Examples: Charcot-Marie-Tooth Disease (CMT) is an established inherited neuropathy leading to muscle weakness and sensory loss, predominantly affecting feet and hands.

Summary
There are many types of neuropathy with differing causes and presentation syndromes. Peripheral neuropathy, autonomic neuropathy, and focal neuropathy are the most common, typically the result of chronic conditions like diabetes. Polyneuropathy and radiculopathy are also common, as is traumatic neuropathy, autoimmune neuropathy, genetic neuropathy, or toxic neuropathy. The diagnosis of the type of neuropathy is necessary to determine the best treatment strategy, as the treatments can be significantly different based on etiology.

Would you like to know more about any particular type of neuropathy or its treatment?


Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.