The Parkinson’s Protocol™ By Jodi Knapp Parkinson’s disease cannot be eliminated completely but its symptoms can be reduced, damages can be repaired and its progression can be delayed considerably by using various simple and natural things. In this eBook, a natural program to treat Parkinson’s disease is provided online. it includes 12 easy steps to repair your body and reduce the symptoms of this disease. The creator of this program has divided into four segments to cover a complete plan to treat this disease along with improving your health and life by knowing everything about this health problem. The main focus of this program is on boosting the levels of hormone in your brain by making e a few easy changes in your lifestyle, diet, and thoughts
What are dyskinesias and how are they treated?
Dyskinesias are involuntary, erratic, often writhing or jerky movements that can affect the face, arms, legs, or trunk. They are a common complication of long-term use of levodopa, the most effective medication for Parkinson’s disease (PD). Dyskinesias can be mild and manageable, or severe enough to interfere with daily life.
🧠 What Causes Dyskinesias?
Dyskinesias are usually caused by:
Long-term levodopa use (especially in people with young-onset Parkinson’s)
Fluctuating dopamine levels in the brain (peaks and troughs due to medication timing)
Disease progression affecting the brain’s ability to regulate dopamine
They often occur when levodopa levels are peaking (“peak-dose dyskinesias”), but can also occur when medication is wearing off.
🧪 Types of Dyskinesias
Type Description
Peak-dose dyskinesia Occurs when levodopa is at its highest effect
Diphasic dyskinesia Happens as medication levels rise and fall
Off-period dystonia Painful twisting/spasms when levodopa wears off
💊 How Are Dyskinesias Treated?
1. Adjusting Levodopa Doses
Smaller, more frequent doses may reduce dopamine spikes.
Controlled-release formulations might help smooth fluctuations.
2. Add-On Medications
Amantadine (Gocovri or Osmolex ER): The only medication specifically approved to treat levodopa-induced dyskinesia.
MAO-B inhibitors (e.g. selegiline, rasagiline): May allow for lower levodopa doses.
COMT inhibitors (e.g. entacapone, opicapone): Help prolong levodopa’s effects.
3. Deep Brain Stimulation (DBS)
A surgical option for advanced PD.
Targets areas like the subthalamic nucleus or globus pallidus interna.
Can reduce levodopa needs and dyskinesias.
4. Levodopa-Carbidopa Intestinal Gel (LCIG)
Provides continuous levodopa delivery via a pump into the small intestine.
Helps flatten dopamine levels and reduce motor fluctuations and dyskinesia.
🌿 Lifestyle and Support Strategies
Consistent medication timing
Low-protein diet timing: Helps levodopa absorption
Physical therapy: Helps manage movement complications
Education: Understanding medication timing and symptom tracking
📌 Summary
Approach Role in Treatment
Medication timing changes Reduce dopamine spikes
Amantadine Primary drug for dyskinesia
Surgical options (DBS) For advanced, medication-refractory cases
LCIG pump For continuous levodopa delivery
Physical and dietary support Complements medication strategies
If you’re considering changes to treatment or exploring surgical options, a consultation with a movement disorder specialist (neurologist) is essential.
Would you like help understanding whether your symptoms fit dyskinesia or finding resources in your region?
The “on-off” phenomenon in Parkinson’s disease refers to sudden, unpredictable fluctuations in a patient’s ability to move, related to the effects of medication—most commonly levodopa.
🟢 “On” State
The medication is working effectively.
Symptoms like tremor, stiffness, and slowness of movement are well controlled.
The person can move more easily and function relatively normally.
🔴 “Off” State
The medication’s effect wears off before the next dose.
Parkinson’s symptoms re-emerge or worsen: rigidity, slowness, difficulty walking, freezing, etc.
Can also include non-motor symptoms like anxiety, fatigue, or pain.
🕒 Types of Fluctuations
Wearing-off: Gradual return of symptoms before the next dose.
Sudden off: Unpredictable and rapid loss of medication effect.
Delayed on: Slower-than-expected response after taking medication.
No on: Medication dose has little or no effect.
⚠️ Why It Happens
Over time, the brain’s ability to store and buffer dopamine decreases.
As Parkinson’s progresses, dopaminergic neurons decline, making the brain more dependent on external sources (levodopa).
The therapeutic window narrows, making timing and dose more critical.
🛠️ Management Strategies
Adjusting medication timing or formulation (e.g., extended-release levodopa).
Adding adjunct medications (e.g., COMT inhibitors, MAO-B inhibitors, dopamine agonists).
Fractionating doses—smaller, more frequent dosing.
Advanced therapies: Deep brain stimulation (DBS), apomorphine infusion, or duodopa intestinal gel may be considered for severe cases.
✅ Summary
The “on-off” phenomenon is a hallmark of advancing Parkinson’s, where motor symptoms unpredictably fluctuate based on medication cycles. It can be frustrating but is manageable with the right treatment strategy.
Would you like guidance on treatment options or how this affects daily life?
The Parkinson’s Protocol™ By Jodi Knapp Parkinson’s disease cannot be eliminated completely but its symptoms can be reduced, damages can be repaired and its progression can be delayed considerably by using various simple and natural things. In this eBook, a natural program to treat Parkinson’s disease is provided online. it includes 12 easy steps to repair your body and reduce the symptoms of this disease. The creator of this program has divided into four segments to cover a complete plan to treat this disease along with improving your health and life by knowing everything about this health problem. The main focus of this program is on boosting the levels of hormone in your brain by making e a few easy changes in your lifestyle, diet, and thoughts