What are the risk factors for developing neuropathy?

May 14, 2025


Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.


What are the risk factors for developing neuropathy?

There are several risk factors for neuropathy development, and they can vary depending on the cause of nerve damage. The following are the most common risk factors:

???? Medical Conditions
Diabetes (especially poorly controlled)

The most common cause of peripheral neuropathy is diabetic neuropathy. High blood sugar levels can damage nerves chronically.

Vitamin Deficiencies

B12, B1 (thiamine), B6, and Vitamin E deficiency can lead to neuropathy.

Chronic Kidney Disease

Toxins the body holds due to kidney failure can lead to nerve damage.

Autoimmune Diseases

Lupus, rheumatoid arthritis, and Guillain-Barré syndrome are diseases that can cause the immune system to attack and damage nerves in error.

Hypothyroidism

Low levels of thyroid hormones can affect the functioning of nerves.

Cancer and Cancer Treatments

Certain cancers, like lymphoma or multiple myeloma, can lead to nerve damage. Some chemotherapy drugs are prone to have neuropathy as a side effect.

Infections

Infections like shingles (herpes zoster), HIV/AIDS, Lyme disease, and Hepatitis C can lead to neuropathy.

Neurological Disorders

Conditions like Parkinson’s disease or multiple sclerosis can damage nerve function.

???? Lifestyle Factors
Excessive Alcohol Consumption

Chronic alcohol intake can lead to alcoholic neuropathy through direct nerve toxicity and nutritional deficiencies (especially B vitamins).

Obesity

Obesity predisposes a person to developing conditions like diabetes, hypertension, and high cholesterol levels, which predispose to neuropathy.

Poor Diet

A diet low in required nutrients (e.g., vitamins B12, B1, B6) may increase the risk for nerve injury.

Smoking

Smoking reduces blood flow and limits oxygen and nutrients from entering nerve tissue, causing nerve injury.

⚠️ Environmental Exposures
Toxins and Chemicals

Contact with industrial chemicals (e.g., solvents, pesticides) and metals such as lead or mercury may damage nerves.

Medications

Certain medications, especially those used in chemotherapy (e.g., vincristine), and HIV or seizure medications, as a side effect, can induce neuropathy.

Repetitive Trauma

Physical trauma or pressure repeatedly placed on nerves (e.g., carpal tunnel syndrome, compression injury) can induce neuropathy.

???? Genetic Factors
Inherited Neuropathies

There are certain genetic disorders, such as Charcot-Marie-Tooth disease (CMT), that increase the risk of developing neuropathy. Family history is involved in some cases.

???? Age
Advanced age increases the risk of developing neuropathy, especially with age-related susceptibility to diseases like chronic diseases of diabetes, kidney, and vascular diseases, which are all nerve impairment diseases.

????‍⚕️ Gender
♀ Males are slightly more likely to be at risk of developing specific neuropathy disorders, most often hereditary in origin like Charcot-Marie-Tooth disease.

???? In Summary:
Diabetes, alcoholism, vitamin deficiencies, chronic kidney or liver disease, autoimmune diseases, and repetitive trauma are all major risk factors for neuropathy. Family history, age, and unhealthy lifestyle habits (such as smoking and obesity) may also put you at increased risk.

If you’d like to learn more about any of these risk factors or would like advice on minimizing your risk, just let me know!

Neuropathy—nerve injury that can affect sensation, movement, and organ function—can have a considerable impact on daily life depending on the location and degree of injured nerves. Here’s how it generally interferes with day-to-day functioning:

???? Physical Effects on Day-to-Day Activities
Pain and Discomfort

Intense, burning, or shooting pain (generally in hands or feet) can be continuous or intermittently flare up unpredictably.

Pain generally gets worse at night, disrupting sleep and leading to daytime tiredness.

Numbness or Tingling

Numbness or tingling in the hands or feet can interfere with walking or dexterity to manipulate objects (e.g., utensils or telephones).

Increases risk for injury, burns, or pressure sores—especially in people with diabetes.

Muscle Weakness

May have difficulty gripping objects, opening jars, or climbing stairs.

In late stages, leads to loss of mobility or reliance on a walking aid.

???? Functional Limitations
Balance Issues

Loss of position sense in the feet results in frequent falling.

Individuals may be unstable even on flat surfaces.

Coordination Problems

Fine motor skills—writing, buttoning a shirt, or using a phone—may be impaired.

Bladder or Bowel Dysfunction (Autonomic Neuropathy)

Urinary urgency, retention, or incontinence.

Diarrhea or constipation, which disrupt comfort and routine.

???? Emotional and Social Impacts
Strain on Mental Well-being

Pain and disrupted sleep can lead to depression, anxiety, and irritability.

Fear of falling or physical impairment may reduce confidence and independence.

Loneliness

Physical impairment or embarrassment about symptoms (e.g., incontinence or unsteady gait) may result in social withdrawal.

???? Occupational and Lifestyle Problems
Work Problems

Heavy or fine-motor work can become impossible or extremely difficult.

Medical appointments or symptom management can reduce productivity.

Exercise and Leisure Activities

Pain or instability can limit ability to stay active or participate in activities like gardening, biking, or cooking.

Difficulty Driving

Blunted sensation or reflexes in the foot can make driving unsafe.

???? Long-Term Health Risks
Infections: Especially in diabetics, asymptomatic foot trauma can lead to deep infection or ulceration.

Amputations: In extremely severe cases with impaired wound healing, neuropathy can cause amputation need.

Digestive Complications: Nerve damage in the gut can lead to nausea, bloating, or malnutrition due to slowed digestion.

???? What Can Help?
Physical therapy for strength and balance.

Pain management (medications, topical, acupuncture).

Assistive devices (braces, orthotics, canes).

Mental health care (peer groups, counseling).

Foot care to prevent unrecognized injury or infection.

Diet and exercise to manage underlying causes such as diabetes.

If you’re living with neuropathy or taking care of someone who is, I can give you personalized advice on symptom management or adapting daily activities. Would you like help with that?


Neuropathy No More By JODI KNAPP Neuropathy No More is an eBook which is a compilation of all the essential information and details about the nervous system and how to keep it active and healthy. With the help of this program, one can get a relief from the symptoms of neuropathy. This eBook not only tells you about the nervous system, but also helps to provide essential information to get relief from the condition of neuropathy. It also provides information about how you can prevent this condition from coming back in the near future.